Imp-1/crd-bp function

Author: rlxi

August undefined, 2024

WitrynaCRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper … Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD …

Regulation of RNA-binding by KH domains of CRD-BP - CORE

Witryna31 lip 2009 · Similarly, the half-life of a GBG mutant lacking an miR-183-binding site was not affected by CRD-BP, as compared to GBG containing the wild-type 577–1182 nt fragment of βTrCP1 (Figure 3 E). Knockdown of CRD-BP reduced expression of βTrCP1, but failed to do so when the function of miR-183 was inhibited (Figure 4 A). Witryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism … hiking trails of north cheyenne canyon

IGF2BP1 insulin like growth factor 2 mRNA binding …

Witryna19 lis 2004 · CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that bind to the 5′-untranslated region of IGF-II leader 3 mRNA. ... In summary, our results revealed a novel function for CRD-BP in cell proliferation involving an IGF-II-dependent mechanism that appears independent of … WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. Witrynaprotein. CRD-BP was later shown to be identical to IMP-1 (14, 19). CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that … small white dog with pointy ears

C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in …

RNAâ binding IMPs promote cell adhesion and invadopodia …

WitrynaDownload scientific diagram siRNA-mediated reduction of CRD-BP/IMP1 mRNA levels . A, efficiency of siRNA uptake by MCF-7 cells. MCF-7 cells were transfected with a control non-silencing ... Witryna9 paź 2013 · High levels of CRD-BP that are found in primary human colorectal tumours exhibiting active beta-catenin/Tcf signalling implicates CRD-BP induction in the upregulation of beta TrCP1, in the ... small white dog with curly tailWitrynapreferentially to distinct CRD-BP KH domains. The novel insights revealed in this study have important implications on the understanding of the oncogenic mechanism of CRD-BP a well as in the future design of inhibitors against CRD-BP function. Coding region determinant-binding protein (CRD-BP; mouse), also known as IMP1 (human), hiking trails off 119 in townsend

"WitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … " - Imp-1/crd-bp function

Imp-1/crd-bp function

Expression of oncofetal RNA‐binding protein CRD‐BP/IMP1 …

Witryna5 maj 2008 · Inhibition of β-TrCP function sensitizes human ... (2001). C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. ... (2007). CRD-BP shields c-myc and ... Witryna4 cze 2007 · The probability of differences in overall survival as a function of time was determined by Kaplan–Meier test, with probing for significance by applying log-rank …

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WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, … Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD …

The mouse Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein. CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1 and the human forms of the protein IMP-1, IMP-2 and IMP-3. Because of their close … Zobacz więcej CRD-BP is a 577 amino acid protein that contains 4 KH domains, 2 RRMs and a RGG box (Figure 2). CRD-BP and human IMP-1 are not identical but shows a high degree of resemblance. They are very closely related … Zobacz więcej CRD-BP and its orthologs have been shown to have the ability to bind CD44, beta-actin, c-myc, IGF2, H19 and tau RNA transcripts. CRD-BP has been shown to play a crucial role in cancer growth and invasion of tissues. CD44 proteins belong to a family of … Zobacz więcej WitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul...

WitrynaUpper panel, analysis by gel electrophoresis of CRD-BP/IMP1 amplicons. 1, BM CD34 cells cultured in plain medium; 2, medium containing 5azaC; 3, medium containing the cytokines mixture; 4, medium ... Witryna18 maj 2010 · Molecular Function: translation regulator activity Source:BHF-UCL. 1 publication. ... IMP-1; IMP1. Alternative names. Coding region determinant-binding …

Witryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis of human colorectal ... P. et al. C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. ...

WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ... hiking trails off rt. 20 massachusettsWitryna9 kwi 2024 · CRD-BP has a dominant role in proliferation of human K562 cells by an IGF-II-dependent mechanism independent of its ability to serve as a c-myc … small white dogs for saleWitryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, … small white dogsWitryna1 paź 2010 · Europe PMC is an archive of life sciences journal literature. Introduction. CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, … small white dog wormsWitryna6 paź 2001 · CRD‐BP/IMP‐1 belongs to a family of RNA‐binding proteins containing 2 RRMs and 4 KH domains; it plays a role in the posttranscriptional control of both … hiking trails off 410 near cliffdaleWitryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis of human colorectal ... P. et al. C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in … small white dogs that don\u0027t shedWitrynaIMP-1 Recombinant Protein (Cat. No. 39-901) has been validated for use in E and WB. ... ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding … hiking trails of the lower applegate book