Previous biological studies have revealed that cotylenin A combined in treatment can program cell death for a wide range of human cancer cell lines and suppress tumor growth. In addition, cotylenin A was found to induce the differentiation of myeloid leukemia cells when combined with a specific pharmaceutical drug. WebJan 1, 1998 · The structure of cotylenin A, a potent plant-growth stimulant with the most complex molecule in cotylenins from Cladosporium fungus sp. 501-7W, was analyzed …
Cotylenin A inhibits cell proliferation and induces apoptosis and
WebJul 1, 2008 · Cotylenin A or IPA immediately induced the expression of S100P mRNA and protein, and the differentiation of HL-60 cells was suppressed by treatment with antisense oligonucleotides against S100P, which suggests that S100P plays an important role in cell differentiation [28]. Cotylenin A enhanced the LCA acetate-induced differentiation … WebSep 28, 2024 · Cotylenin A and fusicoccin A are two flagship members of the fusicoccane diterpenoid family that are capable of acting as molecular glues to stabilize the … brandweer controle
Eleven-Step Chemoenzymatic Synthesis of Cotylenol
WebJul 14, 2024 · Cotylenin A and fusicoccin A (Fig. 7.1) are structurally related diterpene glucosides, which were isolated from different sources of Cladosporium sp. 501-7 W [1,2,3] and Phomopsis amygdali [], respectively.Although both these compounds exhibit potent plant growth activity, biological studies revealed that only cotylenin A induces the … WebMar 1, 2014 · Brassicicene K (2) exhibited similar cytostatic profiles to that of cotylenin A (7), and brassicicenes J (1), A (3), B (4), and F (5) exhibited necrotic activity. This is the first report of the seed dormancy breaking activity of brassicicenes in plants, and of necrotic/apoptotic activity in mammalian cells. WebSep 29, 1997 · Cotylenins had been isolated as the plant-growth regulators, and have been found to affect a number of physiological processes of higher plants. Here we report that … brandweer container